Tottenham Hotspur vs Southampton: Betting Odds, Lineups, Predictions, Preview

Explore our detailed preview for Tottenham vs Southampton in the Premier League. Stats, odds, predictions, and lineups for the 14:00 BST match.

Fixture: Tottenham Hotspur vs Southampton
Date: Sunday 6 April 2025
Kick-off: 14:00 BST
Venue: Tottenham Hotspur Stadium

Given the current form and standings, Spurs are likely to dominate possession and create more scoring opportunities. Southampton, however, will be desperate for points and may adopt a more defensive approach, looking to counter-attack. The match could be closely contested, but Spurs' superior quality and home advantage should see them through.

Match Prediction: Spurs 2-0 Southampton

Spurs have had a mixed bag of results in their recent outings, managing just one win from their last five Premier League matches. They have also struggled in home games against the lower-ranked teams this season, losing to both Ipswich and Leicester, so this could be a potential banana skin for Tottenham despite being heavy favourites.

Last 5 league matches:

• Loss: 0-1 vs Chelsea (A)
• Loss: 0-2 vs Fulham (A)
• Draw: 2-2 vs Bournemouth (H)
• Loss: 0-1 vs Man City (H)
• Win: 4-1 vs Ipswich (A)
  

Southampton's recent form has been challenging, but a draw at home against Crystal Palace will have lifted spirits ahead of this one. The team is in dire need of a win to boost an unlikely push for survival, but with just two wins to their name all season, it doesn't look too likely here.

Last 5 league matches:

• Draw: 1-1 vs Crystal Palace (H)
• Loss: 1-2 vs Wolves (H)
• Loss: 1-3 vs Liverpool (A)
• Loss: 0-4 vs Chelsea (A)
• Loss: 0-4 vs Brighton (H)
  

In their recent encounters, the head-to-head record between Spurs and Southampton has been competitive, but when Spurs win, they seem to win by a huge margin.

Results suggest that while Spurs have had the upper hand in some recent matches, Southampton have shown the ability to compete and even secure victories against them.

• Southampton 0-5 Spurs (15 December 2024)
• Southampton 3-3 Spurs (18 March 2023)
• Spurs 4-1 Southampton (06 August 2022)
• Spurs 2-3 Southampton (09 February 2022)
• Southampton 1-1 Spurs (28 December 2021)
  

• Radu Dragusin - Knee
• Kevin Danso - Hamstring
• Dejan Kulusevski - Foot
• Richarlison - Calf (Doubtful)

With crucial attacking options potentially missing out, Spurs may well struggle to break down a desperate Southampton defence.

• Ryan Fraser - Knock
• Flynn Downes - Suspended
• Paul Onuachu - Knock (Doubtful)
• Lesley Ugochukwu - Knock (Doubtful)
• Ross Stewart - Calf (Doubtful)
• Will Smallbone - Groin (Doubtful)

With some key men potentially missing, Southampton may have to adapt their approach to get anything out of this tough away game.

Vicario; Spence, Romero, van de Ven, Udogie; Bergvall, Bentancur, Maddison; Johnson, Solanke, Son

Ramsdale; Harwood-Bellis, Stephens, Bednarek; Walker-Peters, Aribo, Fernandes, Manning; Dibling, Sulemana, Archer

• Son Heung-Min vs Kyle Walker-Peters: Son's creativity and goal-scoring prowess will be crucial for Spurs, and Walker-Peters will need to be at his best to contain him.
• Brennan Johnson vs Jan Bednarek: Johnson's recent form makes him a key threat, and Bednarek will need to be solid at the back to neutralise him.
• Kyle Walker-Peters vs Destiny Udogie: Both full backs will be keen to join the attack as much as possible, keeping their opposite number on their toes at both ends of the pitch.
  

Spurs have won 26 out of their 49 matches against Southampton in the Premier League, boasting a strong historical advantage over their opponents.

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Odds and market details are accurate as of the time of publication.